A Case of 5-fluorouracil-induced Phototoxicity.
- Author:
Eun Ah CHO
1
;
Si Yong KIM
Author Information
1. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea. dervint@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
5-fluorouracil;
Phototoxicity
- MeSH:
Aged;
Biopsy;
Dermatitis, Phototoxic*;
Erythema;
Fluorouracil;
Humans;
Keratinocytes;
Male;
Skin;
Thymine;
Uracil
- From:Korean Journal of Dermatology
2006;44(11):1364-1366
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
5-fluorouracil (5-FU) is an antimetabolite which prevents thymine synthesis and suppresses the utilization of preformed uracil. A variety of cutaneous reactions have been reported with the use of systemic 5-FU, the most common being photosensitivity. We report a case of 5-FU induced phototoxicity in a 73-year-old male. The patient had tender and slightly pruritic scaly and crusted erythema on sun-exposed areas. A biopsy revealed necrotic keratinocytes with epidermal degeneration. After the cessation of 5-FU, the skin lesions showed a marked improvement, and there was no further photosensitivity to the skin.
