CYP19 Gene Polymorphism in Patients with Endometriosis.
- Author:
Jin Ju KIM
1
;
Young Min CHOI
;
Jun Young HUR
;
Seung Yup KU
;
Jong Kwan JUN
;
Soon Beom KANG
;
Sung Hyo PARK
;
Eun Ran CHANG
;
Noh Hyun PARK
;
Soo Youn CHO
;
In Ae PARK
;
Chang Suk SUH
;
Seok Hyun KIM
;
Jung Gu KIM
;
Shin Yong MOON
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea. ymchoi@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Endometriosis;
CYP19 gene;
Aromatase;
TTTA repeat;
3 bp I/D
- MeSH:
Alleles;
Aromatase*;
Endometriosis*;
Female;
Humans;
Introns;
Laparoscopy;
Laparotomy;
Microsatellite Repeats
- From:Korean Journal of Obstetrics and Gynecology
2005;48(3):726-731
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To explore the association of the CYP19 gene polymorphism with the risk of endometriosis. METHODS: Two hundred seventy-nine women with surgically or histologically diagnosed endometriosis of stages I-IV (ASRM, 1997) were recruited, and two hundred eighteen patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. We analysed the frequency and distribution of a TTTA repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene. RESULTS: Six alleles of the CYP19 gene tetranucleotide repeat polymorphism were found in subjects: from 7 repeats to 13 repeats except 9 repeats. There was no statistically significant difference in the allele distribution of tetranucleotide repeat polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. Also there was no statistically significant difference in the 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. CONCLUSION: These results suggest that tetranucleotide repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism of the CYP19 gene are not associated with the risk endometriosis in the Korean population.
