Connecting Myokines and Metabolism.
10.3803/EnM.2015.30.3.235
- Author:
Rexford S AHIMA
1
;
Hyeong Kyu PARK
Author Information
1. Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. ahima@mail.med.upenn.edu
- Publication Type:Review
- Keywords:
Muscle, skeletal;
Myokine;
Obesity;
Diabetes;
Exercise;
Metabolism
- MeSH:
Adipose Tissue;
Biology;
Brain;
Glucose;
Homeostasis;
Inflammation;
Lipid Metabolism;
Liver;
Metabolism*;
Muscle, Skeletal;
Obesity
- From:Endocrinology and Metabolism
2015;30(3):235-245
- CountryRepublic of Korea
- Language:English
-
Abstract:
Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between muscle and liver, adipose tissue, brain, and other organs. Myokines affect muscle mass and myofiber switching, and have profound effects on glucose and lipid metabolism and inflammation, thus contributing to energy homeostasis and the pathogenesis of obesity, diabetes, and other diseases. In this review, we summarize recent findings on the biology of myokines and provide an assessment of their potential as therapeutic targets.
