Evaluation of the Anti-inflammatory Effect of a Moisturizer Containing Green-Tea Extracts.
- Author:
Sang Woong YOUN
1
;
In A HWANG
;
Jong Yeop YOO
;
Kyoung Chan PARK
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. gcpark@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Anti-inflammatory effect;
Moisturizer;
Green tea extracts
- MeSH:
Dermatitis;
Dermatitis, Atopic;
Eczema;
Erythema;
Hydrocortisone;
Inflammation;
Skin;
Sodium;
Tea
- From:Korean Journal of Dermatology
2003;41(1):15-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: For the long-term management of chronic dermatitis such as atopic dermatitis or xerotic eczema, it is important for a clinician to choose a medication that has the least side effects. OBJECTIVE: We planned to evaluate the anti-inflammatory effect of a moisturizer containing green-tea extracts compared with 1% hydrocortisone lotion. METHODS: The anti-inflammatory effects of 1% hydrocortisone lotion and a moisturizer containing green-tea extracts were evaluated in the inflammation of skin induced by ultraviolet B(UVB) irradiation and sodium lauryl sulfate(SLS) irritation. Twice a day application of topical agents for reducing artificially induced local inflammation was done. Mexameter and chromameter were used for the evaluation of erythema. RESULTS: UVB induced erythema continued to increase regardless of applying topical agents. In contrast, SLS-induced erythema slowly decreased with time duration. Furthermore, increasing pattern of erythema was irregular after UVB irradiation. These results suggest that SLS-induced erythema was more reliable for evaluation of anti-inflammatory effects of topical agent. In addition, we found that a moisturizer containing green tea extracts showed nearly the same effect as or even more effective than 1% hydrocortisone lotion. CONCLUSION: A moisturizer containing green tea extracts would be effective for improving dry skin and also for the treatment of atopic dermatitis or xerotic eczema.
