Metastatic Medullary Carcinoma of Thyroid to Breast; A Case Initially Diagnosed as Primary Invasive Lobular Carcinoma: A Case Report.
- Author:
Youngseok LEE
1
;
Jungsuk AN
;
Chul Hwan KIM
;
Bom Woo YEOM
;
Jong Sang CHOI
;
Yang Seok CHAE
Author Information
1. Department of Pathology, Korea University Anam Hospital, Seoul, Korea. yschae21@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Medullary carcinoma;
Thyroid;
Breast;
Metastasis;
Invasive lobular carcinoma
- MeSH:
Breast*;
Cadherins;
Calcitonin;
Carcinoma, Lobular*;
Carcinoma, Medullary*;
Diagnosis;
Diagnosis, Differential;
Female;
Humans;
Lymphatic Diseases;
Mastectomy, Modified Radical;
Middle Aged;
Neck;
Neck Dissection;
Neoplasm Metastasis;
Thyroid Gland*;
Thyroid Neoplasms;
Thyroidectomy
- From:Korean Journal of Pathology
2007;41(6):412-415
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metastasis to the breast from medullary carcinoma of the thyroid is extremely rare. We report a case of metastatic medullary carcinoma of the thyroid which presented as multiple breast masses with ipsilateral axillary lymphadenopathy in a 48-year-old woman. Six years ago, she underwent total thyroidectomy and neck dissection because of palpable neck masses, with a diagnosis of medullary thyroid carcinoma. Histological features of breast masses showed single- file or linear-cord arrangements, with plasmacytoid appearance, and the initial diagnosis was invasive lobular carcinoma. She underwent modified radical mastectomy. The tumor cells were diffusely positive for E-cadherin, calcitonin and thyroid transcription factor-1 (TTF-1) and were metastatic medullary carcinoma of thyroid. In the patients with a history of medullary carcinoma of the thyroid, a careful examination is necessary for a breast mass composed of solid and cord-like clusters of small round to ovoid cells with plasmacytoid appearance. Immunohistochemical staining for E-cadherin, calcitonin and TTF-1 could be helpful for differential diagnosis.
