Comparison of Treatments in Patients with Inoperable Stage IV Advanced Esophageal Cancer.
10.4166/kjg.2012.59.4.282
- Author:
Gyu Jin LEE
1
;
Moo In PARK
;
Sangeon GWOO
;
Hyun Joo JUNG
;
Joo Hoon KIM
;
Seun Ja PARK
;
Won MOON
;
Hyung Hun KIM
;
Yang Soo KIM
;
Sung Dal PARK
;
Tae Sig JEONG
Author Information
1. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea. mipark@ns.kosinmed.or.kr
- Publication Type:Original Article ; Comparative Study ; English Abstract
- Keywords:
Esophageal cancer;
Drug therapy;
Chemoradiotherapy;
Radiotherapy;
Best supportive care
- MeSH:
Aged;
Aged, 80 and over;
Combined Modality Therapy;
Esophageal Neoplasms/mortality/*therapy;
Female;
Humans;
Kaplan-Meier Estimate;
Male;
Middle Aged;
Neoplasm Staging;
*Palliative Care;
Prognosis;
Retrospective Studies
- From:The Korean Journal of Gastroenterology
2012;59(4):282-288
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to compare palliative treatments such as chemotherapy, chemoradiotherapy or radiotherapy with best supportive care in patients with inoperable advanced esophageal cancer. METHODS: A total of 67 patients with inoperable advanced esophageal cancer visiting Kosin University Gospel Hospital between January 2000 and July 2010 were included in a retrospective analysis. Patients were categorized as having palliative treatment or best supportive care to compare their prognosis. RESULTS: The median survival was 6.4 months in 67 patients. There was significant difference in median survival between the palliative and best supportive treatment (9.8 months vs. 4.5 months, p=0.01). The patients who underwent palliative treatment had superior 1-year and 3-year overall survival rate than those with best supportive treatment (27%, 10% vs. 5%, 5%, respectively). The 1-year and 3-year overall survival rate of palliative treatment was 18% (1-year overall survival rate) in chemotherapy, 33% (1-year overall survival rate) in radiotherapy, 45% and 9% in concurrent chemoradiotherapy, and 20% and 20% in sequential chemoradiotherapy, respectively. CONCLUSIONS: These results may suggest that palliative treatments are more effective than best supportive care. Further prospective studies are still needed to elucidate beneficial effect of palliative treatments on inoperable advanced esophageal cancer.
