Short-term Efficacy of Intravitreal Bavacizumab for Polypoidal Choroidal Vasculopathy.
10.3341/jkos.2009.50.1.51
- Author:
Min Ho LEE
1
;
Jin Hwan AN
;
Ji Eun LEE
;
Boo Sub OUM
Author Information
1. Department of Ophthalmology, Pusan National University Hospital, College of Medicine, Pusan, Korea. bsoum@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Bevacizumab;
Polypoidal choroidal vasculopathy
- MeSH:
Angiography;
Antibodies, Monoclonal, Humanized;
Choroid;
Eye;
Follow-Up Studies;
Humans;
Indocyanine Green;
Intravitreal Injections;
Macular Edema;
Retinal Detachment;
Retrospective Studies;
Tomography, Optical Coherence;
Visual Acuity;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2009;50(1):51-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the short-term effect of intravitreal bevacizumab (Avastin(R)) in polypoidal choroidal vasculopathy. METHODS: Intravitreal Avastin(R) was injected into 13 eyes of 13 patients with PCV in this retrospective, interventional case study. The follow-up period lasted over 3 months after therapy. Changes in best-corrected visual acuity (BCVA), foveal height determined by optical coherence tomography, and abnormal vasculature in indocyanine green angiography (ICGA) were evaluated. RESULTS: The mean LogMAR BCVA was 0.82 at baseline, 0.78 at 1 month after treatment, and 0.73 at 3 months after treatment. Visual acuity was stabilized or improved in 13 eyes (100%). The mean foveal height was 288 micrometer at baseline, 231 micrometer (p<0.05) at 1 month after treatment, and 196 micrometer at 3 months after treatment. The polypoidal lesions in ICGA decreased in 4 eyes (31%), although branching vasculature in ICGA was unchanged in 13 eyes (100%). CONCLUSIONS: Intravitreal injection of Avastin(R) may stabilize visual acuity and reduce macular edema due to decreased retinal pigment epithelial detachment and leaking. However, intravitreal injection had a minimal effect in occlusion of the symptomatic polypoidal lesions and no effect in occlusion of the branching vascular network.
