Determination of Urinary Myo-/Chiro-Inositol Ratios from Korean Diabetes Patients.
10.3349/ymj.2005.46.4.532
- Author:
Tae Sik JUNG
1
;
Jong Ryeal HAHM
;
Jong Jin KIM
;
Jung Hwa JUNG
;
Mi Yeon KANG
;
Sung Won MOON
;
Kang Wan LEE
;
Ho Cheol KIM
;
Jong Deog LEE
;
Ji Hye KIM
;
Deok Ryong KIM
;
Soon Il CHUNG
Author Information
1. Department of Internal Medicine, College of Natural Sciences, Gyeongsang National University, Jinju, Korea. jrhahm@gshp.gsnu.ac.kr
- Publication Type:Original Article
- Keywords:
Myo-inositol;
chiro-inositol;
inositol;
insulin resistance;
diabetes mellitus
- MeSH:
Adult;
Aged;
Diabetes Mellitus, Type 1/*urine;
Diabetes Mellitus, Type 2/*urine;
Female;
Humans;
Inositol/*urine;
Insulin Resistance;
Male;
Middle Aged
- From:Yonsei Medical Journal
2005;46(4):532-538
- CountryRepublic of Korea
- Language:English
-
Abstract:
Of two major forms (myo- and chiro-inositol) of inositols, only chiro-inositol enhances the activity of proteins involved in intracellular glucose metabolism. This study aims to determine the urinary myo-/chiro-inositol ratio in type 1 and type 2 diabetes patients and compare its ratio with the normal control group. The 24-hour urinary myo- and chiro-inositols in 71 Korean diabetes patients and 39 control subjects have been quantified using high-performance liquid chromatography, and their ratios have been evaluated as indices of insulin resistance. The level of 24-hour urinary myo-inositol was significantly higher in both type 1 and type 2 diabetes than with the control group, whereas the urinary chiro-inositol in type 1 or type 2 diabetes was lower than that in normal subjects. The myo-/chiro-inositol ratio in diabetes patients was higher than that in the control group. Twenty four-hour urinary myo-/ chiro-inositol ratios were significantly elevated in type 1 and type 2 diabetes patients compared to the control group, suggesting that a high ratio of urinary myo-/chiro- inositol in type 2 diabetes patients might be used for an index of insulin resistance.
