Antiadhesive Effect of the Mixed Solution of Hyaluronate and Sodium Carboxymethylcellulose After Strabismus Surgery.
10.3341/jkos.2009.50.1.145
- Author:
Sung Wook KWON
1
;
Young Woo SEO
;
Yoonae A CHO
Author Information
1. Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. earth317@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Adehesion;
Sodium carboxymethylcellulose;
Sodium hyaluronate;
Strabismus surgery
- MeSH:
Carboxymethylcellulose Sodium;
Eye;
Fibrosis;
Hyaluronic Acid;
Muscles;
Rabbits;
Sodium;
Strabismus
- From:Journal of the Korean Ophthalmological Society
2009;50(1):145-150
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of the mixed solution of hyaluronate and sodium carboxymethylcellulose (HACMC, Guardix-sol(R)) in reducing postoperative adhesion following strabismus surgery. METHODS: In 16 rabbits out of 20 rabbits, 3 mm recession of the superior rectus muscle was performed on both eyes and HACMC solution was applied only to one eye which was randomly chosen. The rabbits were divided into a surgery-HACMC group and a surgery-no HACMC group. As a control group, the remaining 4 rabbits had no procedures performed. After 3 weeks, both eyes of 8 rabbits with surgery and 2 rabbits of the control group were enucleated. After staining with hematoxylin-eosin and Masson's trichrome, a histologic examination was performed. In the remaining 10 rabbits, the severity of adhesion in muscle and adjacent tissues was observed by blunt dissection. A researcher blind to the experiments performed all the examinations. RESULTS: A significant reduction in the degree of adhesion (P=0.005) as well as decreased fibrosis (P=0.015) was observed in the surgery-HACMC group. CONCLUSIONS: The mixed solution of HACMC was effective in reducing postoperative adhesion after strabismus surgery in rabbits.
