A Study on the Anxiety of the Chronic Viral Hepatitis Patients Receiving Pegylated Interferon Therapy.
10.4306/jknpa.2015.54.4.506
- Author:
Ji Hyun KIM
1
;
Hee Yeon CHOI
;
Tae Hun KIM
;
Soo In KIM
Author Information
1. Department of Psychiatry, School of Medicine, Ewha Womans University, Seoul, Korea. 72sooik@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatitis B;
Hepatitis C;
Anxiety;
Peginterferon alfa-2
- MeSH:
Anxiety*;
Depression;
Hepatitis B;
Hepatitis C;
Hepatitis*;
Humans;
Hypochondriasis;
Interferons*;
Prospective Studies
- From:Journal of Korean Neuropsychiatric Association
2015;54(4):506-514
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to clarify anxiety symptoms associated with the pegylated interferon (PEG-IFN) treatment and to determine which factors are associated with these anxiety symptoms. METHODS: The subjects were 30 patients with hepatitis B and C viral infections who were waiting to receive PEG-IFN treatment. For assessment of depressive and anxiety symptoms, the Beck Depression Inventory and the State-Trait Anxiety Inventory were used. Patients were examined before treatment and then prospectively during the 2 weeks, 4 weeks and 1 years of therapy. We analyzed the changes in anxiety and depression symptoms, and applied multiple regression analysis to identify factors that significantly affect the anxiety symptoms. RESULTS: Compared to pre-treatment baseline, anxiety symptoms increased 2 weeks after treatment, and gradually decreased 4 weeks, and 1 year after treatment. And, we analyzed the sub-factors of depressive symptoms that affect the anxiety symptoms. After 2 weeks of treatment, cognitive-affective factors and hypochondriasis factors of depressive symptoms had an effect on anxiety symptoms. Furthermore after 4 weeks of treatment, the cognitive-affective factors had an effect on anxiety symptoms. CONCLUSION: In this study, we found a significant increase in anxiety symptoms after PEG-IFN treatment, and cognitive-affective depressive factors significantly affect anxiety symptoms.
