New Cocktails for Intracavernous Injection Using KATP Channel Opener, Pinacidil.
- Author:
Du Geon MOON
1
;
Hi Cheol PARK
;
Je Jong KIM
Author Information
1. Department of Urology, Korea University of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Penile erection;
Pinacidil;
Potassium channels
- MeSH:
Adult;
Animals;
Cats;
Diagnosis;
Erectile Dysfunction;
Fibrosis;
Humans;
Male;
Muscle, Smooth;
Papaverine;
Penile Erection;
Penis;
Phentolamine;
Pinacidil*;
Potassium Channels;
Priapism
- From:Korean Journal of Andrology
1999;17(3):163-170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Intracavernous injection of prostaglandin (PG) E1 or papaverine (PA) is widely used in the diagnosis and treatment of erectile dysfunction. Because these drugs are sometimes associated with insufficient erection in and side effects such as priapism, corporal fibrosis, and pain, there has been increasing interest in finding effective and safe alternatives. Recent studies demonstrated that pinacidil (PI) relaxes the smooth muscle. This study was performed to examine the efficacy of PI as an alternative or supplement to drugs such as PG, PA, or phentolamine (PT). MATERIALS AND METHODS: In 28 adult male cats, the maximal intracavernous pressure (ICPmax), time to ICPmax (T1/2) and duration of increased ICP (time) in response to intracavernous injection of PG, PA, or mixture of vasoactive drugs (PA + PT, PA + PG + PT) were compared with the responses to mixtures containing PI (PI + PA, PI + PA + PT,
