Effects of portal hyperperfusion on partial liver grafts in the presence of hyperdynamic splanchnic circulation: hepatic regeneration versus portal hyperperfusion injury.
10.17085/apm.2016.11.2.117
- Author:
Jong Hae KIM
1
Author Information
1. Department of Anesthesiology and Pain Medicine, School of Medicine, Catholic University of Daegu, Daegu, Korea. usmed@cu.ac.kr
- Publication Type:Review
- Keywords:
Liver cirrhosis;
Liver regeneration;
Liver transplantation;
Portal hypertension;
Splanchnic circulation
- MeSH:
Endothelial Cells;
Hemodynamics;
Humans;
Hypertension, Portal;
Liver Cirrhosis;
Liver Regeneration;
Liver Transplantation;
Liver*;
Living Donors;
Physiology;
Regeneration*;
Reperfusion;
Splanchnic Circulation*;
Transplants*
- From:Anesthesia and Pain Medicine
2016;11(2):117-129
- CountryRepublic of Korea
- Language:English
-
Abstract:
In cirrhotic patients undergoing liver transplantation, reperfusion of a liver graft typically increases portal venous blood flow (PVF) because of a decrease in resistance in the liver graft to the PVF and underlying hyperdynamic splanchnic circulation, which develops due to liver cirrhosis complicated by portal hypertension and persists even after successful liver transplantation. If the liver graft has enough capacity to accommodate the increased PVF, the shear stress inflicted on the sinusoidal endothelial cells of the graft promotes hepatic regeneration; otherwise, small-for-size syndrome (SFSS) develops, leading to poor graft function and graft failure. In particular, a partial graft transplanted to patients undergoing living donor liver transplantation has less capacity to accommodate the enhanced PVF than a whole liver graft. Thus, the clinical conditions that the partial graft encounters determine either hepatic regeneration or development of SFSS. Consistent with this, this review will discuss the two conflicting effects of portal hyperperfusion (hepatic regeneration vs. portal hyperperfusion injury) on the partial grafts in cirrhotic patients suffering from hyperdynamic splanchnic circulation, in addition to normal physiology and pathophysiology of hepatic hemodynamics.
