The Effect of Adipose-Derived Stem Cell-Cultured Media on Oxazolone Treated Atopic Dermatitis-Like Murine Model.
- Author:
Hae Jin LEE
1
;
Minyoung JUNG
;
Jae Hong KIM
;
Na Young YOON
;
Eung Ho CHOI
Author Information
- Publication Type:Original Article
- Keywords: Adipose-derived stem cell; Atopic dermatitis; Oxazolone
- MeSH: Animals; Cathelicidins; Dermatitis, Atopic; Epidermis; Intercellular Signaling Peptides and Proteins; Keratinocytes; Mice; Oxazolone; Peptides; Permeability; Phenotype; Stem Cells
- From:Annals of Dermatology 2012;24(2):181-188
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: A stem cell is an undifferentiated cell that has the potential for self-renewal and differentiation. Adipose-derived stem cells (ADSCs) have advantages in accessibility and abundance compared to other kinds of stem cells and produce many growth factors and hormones. OBJECTIVE: We investigated whether ADSC cultured media could be used as a therapy for atopic dermatitis. METHODS: ADSC cultured media was topically applied twice daily for 5 days to oxazolone-treated atopic dermatitis-like hairless mice. RESULTS: Topical application of ADSC cultured media improved the epidermal permeability barrier and keratinocyte differentiation, and restored the predominant Th2 phenotype when compared to vehicle. ADSC cultured media-treated epidermis also showed an increase in the expression of antimicrobial peptides cathelin-related antimicrobial peptide, mouse beta-defensein 3. CONCLUSION: Topical ADSC cultured media could be useful in the treatment of atopic dermatitis.
