The Effect of Acetazolamide on Regional Cerebral Blood Flow in Patients with Ischemic Cerebrovascular Disease.
- Author:
Sang Soo LEE
1
;
Byoung Woo YOON
;
Jae Kyu ROH
;
Sang Bok LEE
;
Ho Jin MYUNG
;
Sang Eun KIM
;
Myung Chul LEE
Author Information
1. Department of Neurology, Seoul National University, Korea.
- Publication Type:Original Article
- MeSH:
Acetazolamide*;
Brain Ischemia;
Carbonic Anhydrases;
Humans;
Perfusion;
Technetium Tc 99m Exametazime;
Tomography, Emission-Computed, Single-Photon
- From:Journal of the Korean Neurological Association
1991;9(3):269-276
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acetazolamide, a selective-inhibitor of carbonic anhydrase. Has been shown to induce a rapid increase in cerebral blood flow by acidifying cerebral extracellular tluid in large doses. In order to assess the cerebral blood flow reserve, we investigated 14 patients with ischemic cerebrovascular disease using Tc-99m HMPAO SPECT before and after administration of acetazolamide.The patients after acetazolamide challenge showed variable pattems of vasodilating capacity which were classified as follows: group I. Accentuation of abnormal perfusion pattem; group II, no change in abnormal perfusion pattern: and group III. Blunting of abnormal perfusion pattern. Thirty-six percent of the patients studied qualified for group I. The p?tients in group I seem to have decreased vasodilating reserve in the area of cerebral ischemia. They are most likely to benefit by medical or surgical efforts to augment CBF delivery. Tc-99m HMPAO-SPECT with acetazolamide flow challenge may serve as an objective. Clinically accessible method for assessing blood flow reserve and as a kind of guide for the therapeutic strategy.
