Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants: by M-mode and Doppler Echocardiography.
- Author:
Eun Jeung KIM
1
;
Eun Sil LEE
;
Young Hwan LEE
;
Son Moon SHIN
;
Jeong Ok HAH
Author Information
1. Department of Pediatrics, School of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Right ventricular systolic time interval;
Patent ductus arteriosus;
Premature infants
- MeSH:
Child;
Ductus Arteriosus;
Ductus Arteriosus, Patent*;
Echocardiography;
Echocardiography, Doppler*;
Heart Rate;
Heart Ventricles*;
Humans;
Infant;
Infant, Newborn;
Infant, Premature*;
Mefenamic Acid;
Pulmonary Artery;
Systole;
Ventricular Function, Right
- From:Journal of the Korean Pediatric Society
1998;41(6):734-740
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery pressure in infants and children and may alter right ventricular afterload thereby right ventricular function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular systolic time interval in premature infants by non-invasive Doppler echocardiography. METHODS: Tweleve premature infants with patent ductus arteriosus were studied by M-mode and Doppler echocardiography before and after treatment with mefenamic acid. Heart rate (HR), ratio of left atrium/aorta (LA/AO), right ventricular preejection period (RVPEP), right ventricular ejection time (RVET) and right ventricular systolic time interval (RVSTI : ratio of RVPEP/RVET), both corrected or uncorrected for heart rate were measured. RESULTS: After mefenamic acid treatment, in infants showing clinical response, right ventricular preejection period (RVPEP) and right ventricular systolic time intetrval (RVSTI), both corrected or uncorrected for heart rate, decreased significantly following ductal closure (RVPEP : 70.3msecc +/- 14.5 vs 54.3msec +/- 10.9, P<0.01, RVPEPc : 129.2msec +/- 13.5 vs 111.7msec +/- 8.4, P<0.01, RVSTI : 0.38 +/- 0.09 vs 0.28 +/- 0.05, P<0.05, RVSTIc : 0.31 +/- 0.04 vs 0.27 +/- 0.03, P<0.01). CONCLUSION: Premature infants with patent ductus arteriosus exhibit echocardiographic evidence of increased RVSTI as a result of increased right ventricular afterload. This results suggest that we have to make every effort to prevent the ductal reopening or early closure of ductus arteriosus in premature infants.
