Antineutrophil Cytoplasmic Antibody in Kawasaki Disease.
- Author:
Soh Yeon KIM
1
;
So Young KIM
;
Wonbae LEE
;
Kyong Su LEE
;
Ji Min KANG
Author Information
1. Department of Pediatrics, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Kawasaki disease;
Antineutrophil cytoplasmic antibody
- MeSH:
Antibodies, Antineutrophil Cytoplasmic*;
Coronary Vessels;
Fever;
Humans;
Immunoglobulins;
Mucocutaneous Lymph Node Syndrome*;
Wegener Granulomatosis
- From:Journal of the Korean Pediatric Society
1998;41(6):808-812
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Antineutrophil cytoplasmic antibody (ANCA) has been identified in various disorders including Wegener's granulomatosis, microscopic polyarteritis and Kawasaki disease. Measuring this antibody has a diagnostic role. It facilitates monitoring disease activity and may also help understand the pathogenesis of the diseases in which it is found. We investigated the correlation between the hematologic findings and ANCA in acute Kawasaki disease and the diagnostic potential of ANCA to predict coronary artery involvement. METHODS: Thirty-eight patients who met the diagnostic criteria for Kawasaki disease were enrolled in this study. We sampled and investigated the hematologic findings and the assay of ANCA before intravenous immunoglobulin treatment and weekly echocardiographs weekly. RESULTS: There was no sexual difference between ANCA positive and negative group. The age in ANCA positive group was significantly lower than in ANCA negative group. Duration of fever before treatment in ANCA positive group were not significantly different from those in ANCA negative group. In ANCA positive group, the mean WBC count and the mean ESRs were higher than in ANCA negative group. There was no relation between ANCA and coronary artery involvement. CONCLUSION: The assays of ANCA in acute Kawasaki disease does not help to predict disease activity and coronary artery involvement.
