A Case of Transient Aplastic Crisis Induced by Human Parvovirus Bl9 in Hereditary Spherocytosis.
- Author:
Kyeong Seob SHIN
;
Bo Ra SON
;
Do Hoon LEE
- Publication Type:Case Report
- MeSH:
Adolescent;
Anemia;
Arthralgia;
Bone Marrow;
Cytoplasm;
DNA;
DNA Viruses;
Erythema;
Erythroblasts;
Female;
Humans*;
Hydrops Fetalis;
Immunocompromised Host;
Inclusion Bodies;
Osmotic Fragility;
Pancytopenia;
Parvovirus B19, Human;
Parvovirus*;
Polymerase Chain Reaction;
Pregnant Women;
Splenomegaly
- From:Korean Journal of Clinical Pathology
1997;17(6):928-933
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Human parvovirus B19 is a single-strand DNA virus which causes erythema infectlosum, arthralgia, aplastic crisis in patients with red cell defect, chronic anemia in immunocompromised patients, and fetal hydrops in pregnant women . A 16-year-old women was referred to our hospital with pancytopenia and splenomegaly. In peripheral blood, spherocytosis and reitculocytopenia were observed. Many giant pronormoblasts with prominent inclusion bodies and deeply blue cytoplasm were observed but late erythroblasts were not observed in bone marrow smear. Osmotic fragility of patient's red cells was significantly increased. Human parvovirus Bl9 DNA was detected by polymerase chain reaction. Only with supportive therapy, pancytopenia was spontaneously resolved.
