A Case of Infectious Mononucleosis-like Syndrome Induced by Sulfasalazine.
- Author:
Ju Ho DO
1
;
Woo Jin CHUNG
;
Hye Soon KIM
;
Keun Gyu PARK
;
Young Rok DO
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. dojuho@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Sulfasalazine;
Infectious mononucleosis;
Hypersensitivity
- MeSH:
Antirheumatic Agents;
Arthritis, Rheumatoid;
Exanthema;
Fever;
Humans;
Hypersensitivity;
Infectious Mononucleosis;
Liver Diseases;
Lymphatic Diseases;
Lymphocytosis;
Rheumatic Diseases;
Splenomegaly;
Sulfasalazine*
- From:Korean Journal of Medicine
2005;68(6):712-716
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sulfasalazine, one of disease modifying anti-rheumatic drugs, is widely used in various rheumatic diseases. Very rarely, sulfasalazine causes drug-associated hypersensitivity syndrome that resembles infectious mononucleosis. Clinical signs include fever, lymphadenopathy, maculopapular skin rash and multivisceral involvement which appear 2 to 5 weeks after administration of drug. Atypical lymphocytosis, liver dysfunction and splenomegaly are also frequently observed. Severe infectious mononucleosis-like syndrome in sulfasalazine treated patients can be caused by reactivation of viruses such as human herpes virus-6, that often result in hypersensitivity syndrome. We report a case of patient who developed infectious mononucleosis-like syndrome after administration of sulfasalazine for the treatment of rheumatoid arthritis. This case warrents careful observation for infectious mononucleosis-like syndrome after sulfasalazine treatment.
