Double Minutes Containing C-MYC oncogene with a Normal Karyotype in Acute Myelogenous Leukemia: A Case Report.
- Author:
Han Sung KIM
1
;
Hyoun Chan CHO
;
Yeonsook MOON
;
Chung Hyun NAHM
;
Jong Weon CHOI
;
Sang Gon YI
;
Sun Hee KIM
Author Information
1. Department of Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea.
- Publication Type:Original Article
- Keywords:
Double minutes;
Acute myeloid leukemia;
C-MYC
- MeSH:
Cytarabine;
Female;
Fluorescence;
Humans;
In Situ Hybridization;
Interphase;
Karyotype*;
Leukemia, Myeloid, Acute*;
Metaphase;
Oncogenes*
- From:The Korean Journal of Laboratory Medicine
2005;25(3):152-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of a female karyotype that was normal except for double minutes (dmin) in acute myeloid leukemia. Using fluorescence in situ hybridization, the amplification of C-MYC was detected in both interphase and metaphase cells. The patient of the present case had received only limited therapy with cytosine arabinoside, but lived for more than one year. It supports the recent notion that dmin may not necessarily be associated with a poor outcome.
