Confocal Microscopy in the Esophagus and Stomach.
- Author:
Adam TEMPLETON
1
;
Joo Ha HWANG
Author Information
1. Division of Gastroenterology, Department of Medicine, University of Washington, School of Medicine, Seattle, WA, USA. jooha@u.washington.edu
- Publication Type:Review
- Keywords:
Microscopy, confocal;
Gastric intestinal metaplasia;
Barrett esophagus;
Dysplasia
- MeSH:
Barrett Esophagus;
Biopsy;
Endoscopy;
Epithelium;
Esophagus;
Humans;
Light;
Mass Screening;
Microscopy;
Microscopy, Confocal;
Phenobarbital;
Stomach;
Stomach Neoplasms
- From:Clinical Endoscopy
2013;46(5):445-449
- CountryRepublic of Korea
- Language:English
-
Abstract:
Probe-based confocal microscopy (pCLE) is actively being investigated for applications in the esophagus and stomach. The use of pCLE allows real-time in vivo microscopy to evaluate the microarchitecture of the mucosal epithelium. pCLE appears to be particularly useful in identifying mucosal dysplasia and early malignancies that cannot be clearly distinguished using high-definition white light endoscopy, chromoendoscopy, or magnification endoscopy. In addition, the ability to detect dysplastic tissue in real-time may shift the current screening practice from random biopsy to targeted biopsy of esophageal and gastric cancers and their precursor lesions. We will review the use of pCLE for detection and surveillance of upper gastrointestinal early luminal malignancy.
