Examination of the Effects of Vardenafil on Esophageal Function Using Multichannel Intraluminal Impedance and Manometry.
- Author:
Tae Hee LEE
1
;
Joon Seong LEE
;
Su Jin HONG
;
Seong Ran JEON
;
Wan Jung KIM
;
Hyun Gun KIM
;
Joo Young CHO
;
Jin Oh KIM
Author Information
1. Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University Seoul Hospital, Seoul, Korea. joonlee@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Manometry;
Phosphodiesterase 5 inhibitor;
Vardenafil
- MeSH:
Eating;
Electric Impedance;
Esophageal Sphincter, Lower;
Fasting;
Humans;
Imidazoles;
Male;
Manometry;
Meals;
Piperazines;
Sulfones;
Swallows;
Triazines;
Water;
Vardenafil Dihydrochloride
- From:Journal of Neurogastroenterology and Motility
2012;18(4):399-405
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS: Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swallows and 10 viscous swallows in a seated position after fasting. Then, each subject was asked to ingest 50 mL distilled water or 10 mg vardenafil dissolved in 50 mL water, in a double-blind manner. After 25 minutes, the MII-EM study was repeated. RESULTS: Eight men received vardenafil and eight subjects received water. Resting and residual lower esophageal sphincter pressures differed significantly only in the vardenafil group (from 18 +/- 6.7 to 6.6 +/- 5.3 mmHg, P < 0.001 and from 4.9 +/- 2.6 to 2.1 +/- 3.6 mmHg, P = 0.006, respectively). Mean distal esophageal amplitude decreased significantly only in the vardenafil group (from 86.7 +/- 41.6 to 34.0 +/- 38.0 mmHg, P < 0.05). Complete bolus transits of liquid and viscous meals decreased significantly only after vardenafil ingestion (from 80.2% +/- 13.8% to 49.4% +/- 27.9%, P < 0.05 and from 72.8% +/- 33.6% to 21.5% +/- 29.0%, P = 0.01, respectively). CONCLUSIONS: Vardenafil decreased esophageal bolus transit in the seated position, despite decreased lower esophageal sphincter pressure.
