A case of minimal change glomerulopathy without interstitial nephritis induced by non-opiate analgesics.
- Author:
Jae Hoon LI
1
;
Hyeok SHIM
;
Joo Jin YEOM
;
Myeung Su LEE
;
Byoung Hyun PARK
;
Seok Kyu OH
;
Nam Ho KIM
;
Moo Rim PARK
;
Seon Ho AHN
;
Ju Hung SONG
Author Information
1. Department of Internal Medicine, School of Medicine Wonkwang University, Iksan, Korea. ashneph@hanmail.net
- Publication Type:Case Report
- Keywords:
Antipyrine;
Anti-inflammatory Agents;
Non-Steroidal;
Nephritis;
Interstitial;
Nephrotic syndrome
- MeSH:
Acute Kidney Injury;
Aged;
Analgesics*;
Anti-Inflammatory Agents;
Antipyrine;
Diclofenac;
Edema;
Female;
Fenoprofen;
Follow-Up Studies;
Hand;
Hemodynamics;
Humans;
Ibuprofen;
Nephritis;
Nephritis, Interstitial*;
Nephrosis, Lipoid*;
Nephrotic Syndrome;
Pathology;
Proteinuria;
Serum Albumin;
Sulindac
- From:Korean Journal of Medicine
2002;63(2):209-213
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The use of nonsteroidal antiinflammatory drugs (NSAIDs) can be complicated by severe forms of renal dysfunction. These include fluid and electrolyte abnormalities, acute renal insufficiency due to alteration in renal hemodynamics, or interstitial nephritis and proteinuria secondary to glomerular pathology, which has the histologic characteristics of minimal change glomerulopathy (MCG). While NSAID-induced nephrotic syndrome characteristically consists of MCG with interstitial nephritis, which is the most common clinical manifestation, it rarely consists of MCG without interstitial nephritis, which has been reported in a handful of patients who took fenoprofen, ibuprofen, sulindac, diclofenac, or zomepirac. We experienced a 66-year-old female patient who presented with low serum albumin, proteinuria and generalized edema and received Geworin for about 2 year before developing symptoms. She histologically had MCG without interstitial nephritis and achieved a complete remission thirty-fifth days after discontinuing the drug. A cause-and-effect relationship of this disease to Geworin administration is strongly suggested by the resolution of the proteinuria after the drug was stopped and by no evidence of any impairment in renal function after twenty eight months of follow-up.
