Esptein-Barr Virus Associated Cutaneous Angiocetric Immunoproliferative Lesion Showing Histologic Features of Classical Lymphomatoid Granulomatosis.
10.5021/ad.1996.8.2.110
- Author:
Doo Hyun CHI
;
Joo Ryung HUH
;
Kyung Jeh SUNG
;
Jai Kyoung KOH
- Publication Type:Case Report
- Keywords:
Angiocentric immunoproliferative lesion;
Epstein-Barr virus
- MeSH:
Biopsy;
Dermis;
Herpesvirus 4, Human;
Histiocytes;
Humans;
In Situ Hybridization;
Lymphocytes;
Lymphomatoid Granulomatosis*;
RNA;
Skin;
Subcutaneous Tissue
- From:Annals of Dermatology
1996;8(2):110-113
- CountryRepublic of Korea
- Language:English
-
Abstract:
We describe a patient with cutaneous angiocentric immunoproliferative lesion (AIL) associated with the Epstein-Barr virus (EBV). An organ system survey revealed no evidence of internal involvement. A skin biopsy specimen .showed infiltrating cells involving mainly deeper dermis and subcutaneous tissue. An examination of the reticular dermis revealed polymorphous angiocentric and angioinvasive infiltrate containing some atypical lymphocytes and histiocytes. EBV encoded RNA (EBER) was demonstrated in lesional skin by the in situ hybridization technique. On the basis of these findings, we conclude that our case may represent a form of AIL associated with EBV showing histologic features of classical lymphomatoid granulomatosis.
