A Case of Malignant Histiocytosis Showing Papulosquamous Skin Lesions and Fever as Initial Manifestations.
10.5021/ad.1996.8.2.117
- Author:
Ji Hwan HWANG
;
Kyu Han KIM
;
Byoung Kook KIM
;
Hyeong Don BANG
;
Kyoung Chan PARK
- Publication Type:Case Report
- Keywords:
Malignant histiocytosis;
Skin lesions;
Fever;
Bone marrow examination
- MeSH:
Bone Marrow Examination;
Child, Preschool;
Cyclophosphamide;
Erythroid Cells;
Female;
Fever*;
Histiocytes;
Histiocytic Sarcoma*;
Humans;
Liver;
Myeloid Cells;
Phagocytosis;
Pigmentation;
Skin*;
Vincristine
- From:Annals of Dermatology
1996;8(2):117-120
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of malignant histiocytosis which began with intermittent fever and scaly skin lesions. A 3-year-old girl presented with erythematous scaly papules on the face and the trunk, and high fever for 3 months. The cutaneous lesions consisted of widespread coin-sized erythematous scaly papules with marginal brownish pigmentation. She was anemic and thrombocytopenic and had impairment of the liver function. Histopathologic study of the skin lesions showed non-specfic findings except for hyperkeratosis. However, bone marrow examination revealed an increased number of histiocytes, mostly immature with active phagocytosis of erythroid cells, myeloid cells, and platelets. She was diagnosed as having malignant histiocytosis and treated with cyclophosphamide and vincristine. She died the next day after the treatment had begun.
