The effects of organophosphate insecticides on the activities of some erythrocyte antioxidant enzymes, total antioxidant status and lipid peroxidation in the blood of workers in insecticide factory
- Author:
Anh Tuan Bui
- Publication Type:Journal Article
- Keywords:
organophosphateinsecticide
- MeSH:
Phosphoric Acid Esters;
Insecticides;
Erythrocytes;
Antioxidants
- From:Journal of Vietnamese Medicine
2001;267(12):1-3
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The workers in insecticide factory generally are exposed to organophosphate insecticide chemicals while working in the plants. We have investigated the effects of organophosphate insecticides on the activities of some erythrocyte antioxidant enzymes, total antioxidant status and lipid peroxidation in the blood of the insecticide producing workers. The results: (1) erythrocyte superoxide dismutase (SOD) and glutathione reductase (GR) activities were significantly depressed by 37.64% and 28.55%, respectively while serum cholinesterase (ChE) activity was only depressed by 13.47% as compared with an unexposed group; (2) erythrocyte glutathione peroxidase (GPx) was increased significantly; (3) serum total antioxidant status (TAS) was depressed by 9.86% (p>0.05). This preliminary study suggests that erythrocyte SOD may be a sensitive indicator of exposure to organophosphate insecticides.
