Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model.
10.5534/wjmh.2017.35.1.43
- Author:
Hyong Woo MOON
1
;
Jung Woo PARK
;
Kyu Won LEE
;
Hyun Cheol JEONG
;
Jin Bong CHOI
;
Sae Woong CHOI
;
Woong Jin BAE
;
Hyuk Jin CHO
;
U Syn HA
;
Sung Hoo HONG
;
Jeong Ho GEUM
;
Seong Bin HONG
;
Sae Woong KIM
Author Information
1. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea. ksw1227@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Antioxidants;
Erectile dysfunction;
Testosterone
- MeSH:
Animals;
Antioxidants;
Arterial Pressure;
Erectile Dysfunction;
Fibrosis;
Guanosine Monophosphate;
Humans;
Infant;
Male;
Models, Animal*;
Neurons;
Nitric Oxide;
Nitric Oxide Synthase;
Oxidative Stress;
Rats*;
Rats, Sprague-Dawley;
Superoxide Dismutase;
Testis;
Testosterone
- From:The World Journal of Men's Health
2017;35(1):43-50
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS AND METHODS: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined. RESULTS: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis. CONCLUSIONS: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
