Levofloxacin and Torsades de Pointes.
10.4046/trd.2010.69.6.474
- Author:
Se Ah KWON
1
;
Cheol Hong KIM
;
Won Jun SONG
;
Ja Kyung KOO
;
Soon Jae LEE
;
Ji Young PARK
;
In Gyu HYUN
;
Jang Hyu KO
;
Hyun Soo KIM
Author Information
1. Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea. kimch2002@hallym.or.kr
- Publication Type:Case Report
- Keywords:
levofloxacin;
Torsades de Pointes
- MeSH:
Anti-Bacterial Agents;
Arrhythmias, Cardiac;
Bradycardia;
Burns;
Electrocardiography;
Fluoroquinolones;
Humans;
Intracranial Hemorrhages;
Ofloxacin;
Torsades de Pointes
- From:Tuberculosis and Respiratory Diseases
2010;69(6):474-479
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Torsades de pointes associated with a prolonged QT interval is a life-threatening arrhythmia, which may be induced by any of the following: drugs, electrolyte imbalances, severe bradycardia and intracranial hemorrhage. Torsades de pointes is characterized by beat-to-beat variations in the QRS complexes in any ECG leads with rates of 200~250 per minute. Fluoroquinolones are widely used and well tolerated antibacterial agents. However, prolongation of the QT interval leads rarely to Torsades de pointes as a significant adverse effect. So, it should be used with caution in high-risk patients for developing Torsades de pointes. We report one case of 67-year old man with contact burns who experienced Torsades de pointes, which probably resulted from the use of levofloxacin, and no further episode occurred after its withdrawal.
