Comparing Quantitative EEG and Low Resolution Electromagnetic Tomography Imaging between Deficit Syndrome and Non-Deficit Syndrome of Schizophrenia.
- Author:
Sang Eun LEE
;
Seon Jin YIM
;
Mi Gyung LEE
;
JaeWon LEE
;
Kyu Hee HAN
;
Jong Il LEE
;
Min Young SIM
;
Hai Joo YOON
;
Byoung Hak SHIN
- Publication Type:Original Article
- Keywords:
LORETA;
Deficit syndrome;
QEEG;
Power spectrum
- MeSH:
Brief Psychiatric Rating Scale;
Electroencephalography;
Humans;
Magnets;
Naphthalenesulfonates;
Proxy;
Schizophrenia
- From:Sleep Medicine and Psychophysiology
2010;17(2):91-99
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Deficit schizophrenia (DS) constitutes a disease separate from non-deficit schizophrenia (NDS). The aim of the current study was to compare the quantitative EEG and low resolution electromagnetic tomography (LORETA) imaging between DS and NDS. METHODS: This study was performed by 32 channels EEG for 42 schizophrenia patients who we categorized into DS and NDS using proxy instrument deficit syndrome (PDS). We performed the absolute power spectral analyses for delta, theta, alpha, low beta and high beta activities. We compared power spectrum between two groups using Independent t-test. Partial correlation test was performed with clinical parameters. Standardized LORETA (sLORETA) was used for comparison of cortical activity, and statistical nonparametric mapping (SnPM) was applied for the statistical analysis. RESULTS: DS showed significantly increased delta and theta absolute power in fontal and parietal region compared with NDS (p<0.05). Power spectrum showed significant correlation with 'anergia' and 'hostility/suspiciousness' subscale of brief psychiatric rating scale (BPRS)(p<0.05). sLORETA found out the source region (anterior cingulate cortex/limbic part) that delta activity was significantly increased in DS (p=0.042). CONCLUSIONS: DS showed different cortical activity compared with NDS. Our results may suggest QEEG and LORETA could be the marker in differentiating between DS and NDS.
