Effect of bovine colostrum on the bacterial translocation and intestinal endotoxemia in 5-fluorouracil treated rats.
- Author:
Jeong Wook KIM
1
;
Woo Kyu JEON
;
Seung Sei LEE
;
Kwon CHOI
;
Jung Won YUN
;
Joon Sup YEON
;
Eun Jeong KIM
;
Myong Suk SHIN
;
Do Hyun LEE
;
Hyo Soon PARK
;
Hong Jin MIN
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. jeonwk@samsung.co.kr
- Publication Type:Original Article
- Keywords:
5-fluorouracil;
Bacterial translocation;
Endotoxins;
Colostrum
- MeSH:
Animals;
Antineoplastic Agents;
Bacterial Load;
Bacterial Translocation*;
Colostrum*;
Drug Therapy;
Endotoxemia*;
Endotoxins;
Fluorouracil*;
Horseshoe Crabs;
Ileum;
Intestine, Small;
Liver;
Lymph Nodes;
Permeability;
Plasma;
Rats*;
Serum Albumin;
Spleen
- From:Korean Journal of Medicine
2004;67(5):513-520
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Antitumor drugs such as 5-fluorouracil (5-FU) are known to induce intestinal damages and bacterial translocation. The present studies examined whether or not bovine colostrum protects against gut barrier damage, bacterial translocation and endotoxemia from these antitumor drugs. METHODS: Rat received either no drug, chemotherapy alone (5-FU, 300 mg/kg intraperitoneal injection) or bovine colostrum (4 g/day per os) for 5 days prior to 5-FU and for 5 days afterward. Intestinal permeability, enteric aerobic bacterial counts, serum albumin and protein levels, and pathologic findings of ileum were measured. Bacterial translocation to systemic blood, mesenteric lymph nodes, liver and spleen were measured. Systemic plasma endotoxin levels were quantified by the chromogenic limulus amebocyte lysate (LAL) technique. RESULTS: 5-FU increase intestinal permeability and plasma endotoxin levels, and decreased serum levels of total protein and albumin. Also 5-FU induced bacterial translocation to mesenteric lymph nodes, liver and spleen, not to systemic blood, but did not induce changes of enteric bacterial numbers and mucosal damages of small intestine. Combined administration of bovine colostrum with 5-FU reduced an increase in intestinal permeability and declines in serum albumin and protein levels by 5-FU. Bovine colostrum supplements also reduced bacterial translocation to mesenteric lymph nodes, liver and spleen, and endotoxemia. CONCLUSION: Bovine colostrums may beneficial effects in preventing 5-FU induced gut barrier damage, bacterial translocation and intestinal endotoxemia.
