Disseminated neonatal herpes simplex virus infection with necrotizing encephalitis: an autopsy case.
10.3346/jkms.1987.2.2.123
- Author:
Yeon Lim SUH
1
;
Hyomin KIM
;
Je G CHI
;
Hye Ran BYUN
;
Keun LEE
Author Information
1. Department of Pathology, Seoul National University Children's Hospital, Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Herpes simplex;
encephalitis;
neonatal infection;
virus infection
- MeSH:
Autopsy;
Brain/pathology;
Encephalitis/*etiology;
Herpes Simplex/*congenital/pathology;
Humans;
Infant, Newborn;
Infant, Premature, Diseases/*pathology;
Liver/pathology;
Male;
Necrosis;
Skin/pathology
- From:Journal of Korean Medical Science
1987;2(2):123-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
An autopsy case of disseminated HSV type 2 infection occurring in a neonate at 32 weeks' gestation, delivered by cesarean section after premature rupture of membrane of 7 days duration, is presented. Herpes simplex virus type 2 was isolated from the vesicular skin lesion. The mother and patient had specific antibody to type 2 herpes simplex virus. Patient's parents had denied any herpetic orolabial or genital lesion during or before this pregnancy. Cultures from the cervical and vaginal swabs of the mother were negative for HSV. Postmortem examination showed hepatic necrosis, skin vesicle, devastating necrotizing inflammation of the brain, chorioretinitis and interstitial pneumonitis.
