Genetic Basis of Parkinson Disease.
- Author:
Keun Hwa JUNG
1
;
Beom S JEON
Author Information
1. Department of Neurology and Clinical Research Institute, Seoul National University Hospital, Neuroscience Research Institute of SNUMRC, Seoul, Korea. brain@snu.ac.kr
- Publication Type:Review
- Keywords:
Parkinson disease;
Genetics
- MeSH:
Dopaminergic Neurons;
Genetics;
Neurodegenerative Diseases;
Parkinson Disease*;
Substantia Nigra
- From:Journal of the Korean Neurological Association
2004;22(4):281-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
Parkinson disease (PD) is a neurodegenerative disease characterized by the selective loss of dopaminergic neurons from the substantia nigra pars compacta leading to the impairment of motor functions. Recent genetic studies have uncovered several genes involved in inherited forms of the disease. These gene products are likely to be implicated in the biochemical pathways underlying the etiology of sporadic PD. Our review discusses the pathogenetic mechanisms of the mutated genes.
