Abnormal Cerebral Glucose Metabolism in Patients with Narcolepsy.
- Author:
Eun Yeon JOO
1
;
Woo Suk TAE
;
Jee Hyun KIM
;
Sun Jung HAN
;
Yong Won CHO
;
Leen KIM
;
Chang Ho YUN
;
Myoung Hee KIM
;
Byung Tae KIM
;
Seung Bong HONG
Author Information
1. Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea. hongsb@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Narcolepsy;
Metabolism;
18F-FDG-PET scan;
Hypothalamus;
Thalamus
- MeSH:
Brain;
Glucose*;
Humans;
Hypothalamus;
Metabolism*;
Narcolepsy*;
Parietal Lobe;
Polysomnography;
Positron-Emission Tomography;
Rabeprazole;
Thalamic Nuclei;
Thalamus;
Orexins
- From:Journal of the Korean Neurological Association
2004;22(4):340-344
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to investigate the differences of cerebral glucose metabolism between narcoleptic patients and normal controls. METHODS: We enrolled 24 patients with narcolepsy who underwent night polysomnography and multiple sleep latency tests to confirm the narcolepsy. 18F-fluorodeoxy glucose positron emission tomography scan was performed in all narcoleptic patients and 24 normal age-sex matched controls. To compare the cerebral glucose metabolism between the two groups, statistical parametric mapping (SPM99) was used. RESULTS: Patients with narcolepsy showed significant decreases of cerebral glucose metabolism in the bilateral rectal and subcallosal gyri, right superior frontal gyrus, right medial frontal gyrus, bilateral precuneus, right inferior parietal lobule, and left supramarginal gyrus of the parietal lobe at the uncorrected P<0.001. The bilateral posterior hypothalami and mediodorsal thalamic nuclei showed glucose hypometabolism at the level of corrected P<0.05 with small volume correction. CONCLUSIONS: This study showed cerebral glucose hypometabolism of hypothalamus-thalamus-orbitofrontal pathways in narcoleptic brains. The distribution of abnormal glucose metabolism is concordant to the cerebral pathways of the hypocretin system.
