Expression of p53 and Vascular Endothelial Growth Factor in Gastric Cancer; Usefullness as Clinical Significance.
- Author:
Sung Hoon KIM
1
;
Pyung Jae PARK
;
Woo Sang RYU
;
Jin KIM
;
Min Young CHO
;
Jeoung Won BAE
;
Chong Suk KIM
;
Young Chul KIM
;
Cheung Wung WHANG
;
Sung Ock SUH
Author Information
1. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea. docsuh@chollian.net
- Publication Type:Original Article
- Keywords:
Gastic cancer;
p53;
Vascular endothelial growth factor (VEGF)
- MeSH:
Genes, Tumor Suppressor;
Humans;
Immunohistochemistry;
Prognosis;
Stomach Neoplasms*;
Survival Rate;
Vascular Endothelial Growth Factor A*
- From:Journal of the Korean Surgical Society
2005;69(3):204-209
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Recent studies have indicated that the p53 tumor suppressor gene and vascular endothelial growth factor (VEGF) play an important role in the angiogenic process of tumors. In this study, the correlation of the expressions of p53 and VEGF and the clinical features in gastric cancer were investigated. METHODS: The expressions of p53 and VEGF in gastric cancer were determined using immunohistochemistry on 98 randomly selected gastric cancer patients that had received curative resection. RESULTS: The expression of p53 and VEGF were observed in 51% and 50% of tumors, respectively. A significant correlation was found between p53 expression and the tumor histological type (P=0.045). The higher the TNM stage, the higher the observed level of p53 expression. The p53 and VEGF expression stati coincided in 70.4% of tumors, with a significant correlation found between the p53 and VEGF stati. Significantly worse survival rates were found in p53-positive and VEGF-positive patients than in those that were p53-negative and VEGF-negative. CONCLUSION: The present results indicated that p53 and VEGF expressions are useful in predicting the prognosis of patients with gastric cancer.
