C-met and E-cadherin Expression in Advanced Gastric Cancer.
- Author:
Seung Tak OH
1
;
Young Don LEE
;
You Jin HWANG
;
Jae Hwan SUH
;
Woon Kee LEE
Author Information
1. Department of Surgery, Gachon Medical School, Gil Medical Center, Incheon, Korea. www.lwk@gilhospital.com
- Publication Type:Original Article
- Keywords:
Advanced gastric cancer;
C-met;
E-cadherin;
Clinicopathological parameters
- MeSH:
Cadherins*;
Down-Regulation;
Humans;
Lymph Nodes;
Multivariate Analysis;
Neoplasm Metastasis;
Prognosis;
Retrospective Studies;
Stomach Neoplasms*
- From:Journal of the Korean Surgical Society
2005;69(3):210-216
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In the current study, the relation between the clinicopathological parameters and levels of the amplification of the c-met and E-cadherin genes were investigated in patients with an advanced gastric carcinoma. METHODS: The levels of amplification of the c-met and E-cadherin genes in 44 advanced gastric carcinoma patients were retrospectively investigated using RT-PCR. The relationships between the levels of amplification of these genes and the clinicopathological parameters were evaluated using univariate and multivariate analyses. RESULTS: Seventeen (38.6%) and 13 (29.5%) of the 44 advanced gastric carcinoma patients were evaluated as having amplification of the c-met gene and down-regulation of the E-cadherin gene, respectivly. The amplification of c- met gene was significantly correlated with serosal invasion, lymph node metastasis and neural invasion, whereas the down-regulation of the E-cadherin gene was significantly correlated with the diffuse type of gastric carcinoma by Lauren's calssification, and neural invasion. CONCLUSION: The levels of the c-met and E-cadherin gene amplifications may be a powerful aids in evaluating the metastatic potential and prognosis in patients with advanced gastric cancer.
