Cord Blood Adiponectin and Insulin-like Growth Factor-I in Term Neonates of Gestational Diabetes Mellitus Mothers: Relationship to Fetal Growth.
10.5385/jksn.2011.18.1.49
- Author:
Jin A SOHN
1
;
Eun Ae PARK
;
Su Jin CHO
;
Young Ju KIM
;
Hyesook PARK
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. pea8639@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Adiponectin;
Insulin-like growth factor-I;
Cord blood;
Gestational diabetes mellitus
- MeSH:
Adiponectin;
Birth Weight;
Body Size;
Diabetes, Gestational;
Female;
Fetal Blood;
Fetal Development;
Gestational Age;
Glucose Tolerance Test;
Humans;
Infant, Newborn;
Insulin Resistance;
Insulin-Like Growth Factor I;
Mothers;
Pregnancy
- From:Journal of the Korean Society of Neonatology
2011;18(1):49-58
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the relationship between cord blood adiponectin and insulin-like growth factor (IGF)-I and their effect on fetal growth and insulin resistance in mothers with gestational diabetes mellitus (GDM). METHODS: Cord blood adiponectin and IGF-I were compared between mothers with GDM (GDM group, N=53) and controls (non-GDM group, N=101). Neonates were classified into three groups of small for gestational age (SGA, N=26), appropriate for gestational age (AGA, N=97), and large for gestational age (LGA, N=31) by birth weight. The association between cord adiponectin and IGF-I levels was evaluated in relation to maternal and neonatal clinical data. RESULTS: Cord adiponectin was lower in the GDM group than in the non-GDM group (P<0.001). There was no significant difference in cord adiponectin among the SGA, AGA, and LGA groups in the GDM group (P=0.228). The cord adiponectin of AGA in the GDM group was significantly lower than that in the non-GDM group (P<0.001). The most powerful predictor affecting cord adiponectin was the result of maternal 75 g oral glucose tolerance test. The cord IGF-I values between the GDM group and the non-GDM group were not different (P=0.834). Neonates with the heavier birth weight had the higher cord IGF-I levels. The most powerful predictor affecting cord IGF-I was birth weight and the next was maternal parity. CONCLUSION: Both cord blood adiponectin and IGF-I were associated with fetal growth, but IGF-I was a more general and direct factor affecting fetal body size, and adiponectin seemed to have more association with insulin sensitivity than growth.
