Expression of Epidermal Growth Factor, Transforming Growth Factor-alpha and Epidermal Growth Factor Receptor in Human Cervical Neoplasia.
- Author:
Bang Hyun LEE
1
;
Dong Jin KWON
;
Chan Joo KIM
;
Yong Ill KWON
;
Tae Chul PARK
;
Jin Hong KIM
;
Jin Woo LEE
;
Do Kang KIM
;
Sung Eun NAMKOONG
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Cervix;
Epidermal growth factor;
Transforming growth factor-alpha;
Epidermal growth factor receptor
- MeSH:
Antibodies;
Antibodies, Monoclonal;
Cell Proliferation;
Cervical Intraepithelial Neoplasia;
Cervix Uteri;
Epidermal Growth Factor*;
Epithelium;
Female;
Humans;
Receptor, Epidermal Growth Factor*;
Transforming Growth Factor alpha;
Uterine Cervical Neoplasms
- From:Korean Journal of Obstetrics and Gynecology
2001;44(2):273-276
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: This study seeks to define the expression of epidermal growth factor(EGF) and transforming growth factor(TGF)-alpha and epidermal growth factor receptor(EGFR), and the relationship to the tumor progression of human cervical epithelial neoplasia. METHODS: To confirm the expression of EGF, TGF-alpha and EGFR immunohistochemically in normal cervix, cervical intraepithelial neoplasms and cervical carcinomas, we used monoclonal antibodies to EGF, TGF-alpha and EGFR. RESULTS: Immunohistochemical stainings using anti-EGF, anti-TGF-alpha and anti-EGFR antibodies showed weak or moderate stainings in all cases. Normal and CIN cases showed predominantly basal and parabasal expression of EGF, TGF-alpha and EGFR, and its expression decreased as the cells became increasingly differentiated toward the surface of the epithelium. In the cervical carcinoma EGF and TGF-alpha expressed weakly to moderately focally, and EGFR expressed intensely in all malignant cells. CONCLUSION: These results suggest that EGF, TGF-alpha and EGFR may involved in cellular proliferation of cervical squamous epithelium and have a significant role in the progression of cervical cancer.
