The Concentration of Estradiol, Testosterone and Insulin-like Growth Factor-I in Follicular Fluid of Patients with Polycystic Ovarian Syndrome Undergoing Controlled Ovarian Hyperstimulation.
- Author:
Sung Hoon KIM
1
;
Hye Eun KWON
;
Eun Ju PARK
;
Hee Dong CHAE
;
Chung Hoon KIM
;
Byung Moon KANG
;
Yoon Seok CHANG
Author Information
1. Division of Rep roductive Endocrinology and Inf ertility, Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article ; In Vitro
- Keywords:
Polycystic ovarian syndrome;
Follicular fluid;
Insulin-like growth factor-I;
Estrogen;
Testosterone
- MeSH:
Embryonic Structures;
Estradiol*;
Estrogens;
Female;
Fertilization in Vitro;
Follicular Fluid*;
Humans;
Insulin-Like Growth Factor I;
Ovary;
Ovum;
Polycystic Ovary Syndrome*;
Testosterone*
- From:Korean Journal of Obstetrics and Gynecology
2001;44(2):296-301
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate microenvironment of follicular fluid, such as estradiol(E2), testosterone(T), and insulin-like growth factor-I(IGF-I) of patients with polycystic ovary syndrome(PCOS) undergoing controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVF-ET). MATERIALS AND METHODS: From January 1996 to June 1998, follicular concentrations of E2, T, and IGF-I on the day of transvaginal ovum aspiration were measured in 40 patients undergoing COH for IVF-ET. The patients were grouped into the control(n=20) and the PCOS(n=20) groups. Statistical analysis was performed using Student's t-test, Fisher's exact test, and X2 test as appropriate. Statistical significance was defined as p<0.05. RESULTS: There were no significant differences in the follicular concentrations of E2, T, and IGF-I between the control and the PCOS groups. CONCLUSION: IGF-I might be not a main component of the local regulatory mechanisms involved in the pathogenesis of PCOS.
