An overlap syndrome of Churg-Strauss syndrome and rheumatoid arthritis.
10.12701/yujm.2015.32.2.127
- Author:
Seung Il BAE
1
;
Jong Geol JANG
;
Hun Tae KIM
;
Hee Yun AHN
;
Min Jung KIM
;
Hyun Je KIM
;
Choong Ki LEE
;
Young Hoon HONG
Author Information
1. Division of Rheumatology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. yhhongdr@yahoo.co.kr
- Publication Type:Case Report
- Keywords:
Churg-Strauss syndrome;
Rheumatoid arthritis;
Mononeuritis multiplex;
Overlap syndrome
- MeSH:
Antibodies, Antineutrophil Cytoplasmic;
Arthritis;
Arthritis, Rheumatoid*;
Biopsy;
Bone Diseases, Metabolic;
Churg-Strauss Syndrome*;
Diagnosis;
Electromyography;
Eosinophilia;
Eosinophils;
Foot;
Hand;
Hematologic Tests;
Humans;
Lymphocytes;
Male;
Middle Aged;
Mononeuropathies;
Neural Conduction;
Neutrophils;
Peripheral Nervous System Diseases;
Peroneal Nerve;
Respiratory Function Tests;
Rheumatoid Factor;
Vasculitis
- From:Yeungnam University Journal of Medicine
2015;32(2):127-131
- CountryRepublic of Korea
- Language:English
-
Abstract:
Churg-Strauss syndrome (CSS) is a necrotizing vasculitis with extra-, peri-vascular eosinophilic infiltration. Chronic symmetric polyarthritis with the presence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody are the mainstay of rheumatoid arthritis (RA) diagnosis. Mononeuritis multiplex is a peripheral neuropathy involving more than 2 separate nerve areas. A 62-year-old male patient was referred for left foot drop and polyarthritis of both hands and feet for 4 months. During evaluation, mononeuritis multiplex was detected on nerve conduction study and electromyography tests: vasculitis with neutrophil, eosinophil, and lymphocyte infiltration on peroneal nerve biopsy. A positive response to methacholin and bronchodilator was observed on the pulmonary function test. Radiologic tests showed peri-articular soft tissue swelling and osteopenia on both hand and foot. Marked peripheral eosinophilia, high RF, and positive perinuclear anti-neutrophil cytoplasmic antibody were detected on blood tests. Here, we report on a patient with overlap syndrome of CSS and RA with review of the relevant literature, from which a few references to overlap syndrome of CSS and RA were available.
