ERCC1 Can Be a Prognostic Factor in Hilar Cholangiocarcinoma and Extrahepatic Bile Duct Cancer, But Not in Intrahepatic Cholangiocarcinoma.
- Author:
Kyun Woo PARK
1
;
Eun Seon JUNG
;
Dong Gu KIM
;
Young Kyung YOO
;
Tae Ho HONG
;
In Seok LEE
;
Yoon Ho KOH
;
Ji Hoon KIM
;
Myung Ah LEE
Author Information
1. Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea. angelamd@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Bile duct neoplasms;
ERCC1;
Prognosis
- MeSH:
Bile Duct Neoplasms;
Bile Ducts, Extrahepatic;
Cholangiocarcinoma;
Cyclin D1;
DNA Repair;
Humans;
Liver Neoplasms;
Lymph Nodes;
Prognosis;
Retrospective Studies;
Sample Size;
Thymidine Phosphorylase;
Cholangiocarcinoma
- From:Cancer Research and Treatment
2013;45(1):63-69
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: There are three types of bile duct cancer, intrahepatic cholangiocarcinoma (ICC), hilar cholangiocarcinoma (HC), and extrahepatic cholangiocarcinoma (EHC). Despite different clinical presentation, the same protocol has been used in treatment of patients with these cancers. We analyzed clinicopathologic findings and protein expression in order to investigate the difference and the specific prognostic factors among these three types of cancers. MATERIALS AND METHODS: We conducted a retrospective review of 104 patients diagnosed with bile duct cancer at Seoul St. Mary's Hospital between January 1994 and May 2004. We performed immunohistochemical staining for p53, cyclin D1, thymidine phosphorylase, survivin, and excision repair cross-complementing group 1 (ERCC1). RESULTS: Of the 104 patients, EHC was most common (44.2%). In pathologic findings, perineural invasion was significantly less common in ICC. Overall survival was similar among the three types of cancer. Lymph node invasion, lymphatic, and venous invasion showed a significant association with survival outcome in ICC, however, the differentiation of histologic grade had prognostic significance in HC and EHC. No difference in protein expression was observed among these types of cancer, however, ERCC1 showed a significant association with survival outcome in HC and EHC, not in ICC. CONCLUSION: Based on our data, ICC showed different characteristics and prognostic factors, separate from the other two types of bile duct cancer. Conduct of further studies with a large sample size is required in order to confirm these data.
