Expression of c-erbB-2 Oncoprotein and DNA Topoisomerase II-alpha in Premalignant Lesions and Invasive Squamous Cell Carcinomas of the Uterine Cervix.
- Author:
Seung Ho SHIN
1
;
Hong Mo KOO
;
Jin Seak KIM
;
Hye Kyoung MUN
;
Jae Deok LEE
;
Sang Yong KIM
;
Jae Hee HAN
;
Tae Il CHO
;
Tae Jin LEE
Author Information
1. Department of Obstetrics and Gynecology, Kwang Myung Sung Ae Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
c-erbB-2;
topoisomerase II-alpha;
uterine cervix;
precancerous lesion;
invasive squamous cell carcinoma
- MeSH:
Carcinoma, Squamous Cell*;
Cervix Uteri*;
DNA Topoisomerases, Type I*;
DNA*;
Female;
Immunohistochemistry;
Receptor, erbB-2
- From:Korean Journal of Obstetrics and Gynecology
2002;45(12):2124-2129
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The relationship was studied between expression of c-erbB-2 oncoprotein and topoisomerase II-alpha as proliferating marker in precancerous lesions and invasive squamous carcinomas of the uterine cervix. METHODS: Total 81 formalin-fixed, paraffin-embedded sections of low-grade intrasquamous lesion (22 cases), high-grade intraepithelial lesions (42 cases) and invasive squamous cell carcinomas (17 cases) in the uterine cervix were stained by immunohistochemistry for expression of the c-erbB-2 oncoprotein and topoisomerase II-alpha. RESULTS: The expression of c-erbB-2 oncoprotein and staining index (mean+/-S.D) of topoisomerase II-alpha were statistically significant between precancerous lesions and invasive carcinoma. The expression of c-erbB-2 oncoprotein has correlation with staining index (mean+/-S.D) of topoisomerase II-alpha. CONCLUSION: There results suggest that the expression of c-erbB-2 protein has relationship with progression of squamous lesions and topoisomerase II-alpha is an useful proliferating marker in the uterine cervix. And, the expression of c-erbB-2 protein has correlation with expression of topoisomerase II-alpha.
