FDG-PET Scan in Patients with Cervical Cancer: Experience in Patients with Clinically No Evidence of Disease.
- Author:
Lee Jae KYU
;
Beob Jong KIM
;
Soon Hyunk HWANG
;
Sang Young RYU
;
Jong Hoon KIM
;
Byoung Gie KIM
;
Sang Yoon PARK
;
Eui Don LEE
;
Kyung Hee LEE
;
Chang Woon CHOI
;
Sang Moo LIM
- Publication Type:Original Article
- Keywords:
Cervical Cancer;
PET scan
- MeSH:
Biopsy, Needle;
Humans;
Magnetic Resonance Imaging;
Mediastinum;
Neoplasm Metastasis;
Positron-Emission Tomography;
Recurrence;
Sensitivity and Specificity;
Uterine Cervical Neoplasms*
- From:Korean Journal of Obstetrics and Gynecology
1999;42(9):2055-2061
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study was to investigate the clinical feasibility of FDG-PET (Positron Emission Tomography) scan in patients with clinically no evidence of disease after treatment of cervical cancer. METHODS: One hundred and one patients with clinically NED(no evidence of disease) state after treatment of cervical cancer underwent PET scan. FDG-PET scan was obtained with a GE Advance Scanner, beginning at 50 minutes after injection of 370-555 MBq(10-15 mCi) of 18F FDG. Regional scan was also obtained with emission image. Uptake exceeding 3.0 SUV was determined as a positive finding. Recurrence was confirmed by CT, MRI, and needle biopsy if possible. RESULTS: Among 101 patients showing no evidence of disease, 17 patients(16.8%) showed abnormal PET scan findings. Clinically, 8 patients(7.9%) were confirmed to have recurrent lesion by CT, MRI or by needle biopsy. PET scan could detect recurrent lesions in the mediastinum or lung(10/17), pelvis(7/17), and supraclavicular lymph node(2/17). The sensitivity and specificity of PET scan in patients with cervical cancer showing no evidence of disease were 100% and 90.3%, respectively. The positive predictive value, negative predictive value and false positive rate were 47.1%, 100% and 52.9%. CONCLUSION: PET scan could detect 7.9% of early recurrence in patients with cervical cancer with NED status. FDG-PET scan may be a useful method in detecting metastases or recurrence of a cervical cancer showing no evidence of disease by routine conventional imaging studies.
