Two Cases of Allopurinol Hypersensitivity Syndrome in Patients Receiving Thiazide Therapy due to Hypertension.
- Author:
Hyun Jeong SONG
1
;
Chang Ook KIM
;
Kyu Suk LEE
Author Information
1. Department of Dermatology, Keimyung University School of Medicine, Taegu, Korea. dermasong@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Allopurinol hypersensitivity syndrome;
Thiazide
- MeSH:
Allopurinol*;
Eosinophilia;
Exanthema;
Fever;
Humans;
Hypersensitivity*;
Hypertension*;
Leukocytosis
- From:Korean Journal of Dermatology
2005;43(10):1426-1429
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allopurinol hypersensitiviy syndrome (AHS) is a rare immunologic response to allopurinol, characterized by multiple findings such as skin rash, fever, hepatic dysfunction, decreased renal function, leukocytosis and eosinophilia. The risk developing AHS tends to increase in patients receiving thiazide therapy or in those who have a pre-existing renal disease. We report two cases of AHS in patients who were taking thiazide medication due to hypertension and underlying renal disease. They developed an erythematous skin rash, fever, renal dysfunction, and eosinophilia after allopurionol therapy.
