DPC4 Expression in the Small Intestinal Adenocarcinomas.
- Author:
Sun Jae LEE
1
;
Eunsil YU
;
Young Kyung BAE
;
Kee Taek JANG
;
Joon Mee KIM
;
Han Ik BAE
;
Seung Mo HONG
;
Ghil Suk YOON
Author Information
1. Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea. gsyoon@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Smad4/DPC4;
Adenocarcinoma;
Intestine, small;
Immunohistochemistry
- MeSH:
Adenocarcinoma;
Cell Transformation, Neoplastic;
Cytoplasm;
Humans;
Immunohistochemistry;
Intestine, Small;
Pancreatic Neoplasms
- From:Korean Journal of Pathology
2012;46(5):415-422
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis. METHODS: We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology. RESULTS: Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival. CONCLUSIONS: The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.
