The Effect of Timing of Ondansetron Administration on Nausea and Vomiting during Intravenous Patient-Controlled Analgesia.
10.4097/kjae.2001.41.1.33
- Author:
Dong Hee KIM
1
;
Duk Hyun CHO
;
Choong Hak PARK
Author Information
1. Department of Anesthesiology, College of Medicine, Dankook University, Cheonan, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Analgesia: patient-controlled;
Pharmacology: ondansetron;
Vomiting: nausea;
postoperative
- MeSH:
Analgesia, Patient-Controlled*;
Anesthesia;
Anesthesia, General;
Butorphanol;
Female;
Humans;
Hysterectomy;
Incidence;
Ketorolac;
Nausea*;
Ondansetron*;
Postoperative Nausea and Vomiting;
Vomiting*
- From:Korean Journal of Anesthesiology
2001;41(1):33-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study was designed to establish the optimal timing of administration of ondansetron for prevention of postoperative nausea and vomiting (PONV) during intravenous patient-controlled analgesia (IV-PCA). METHODS: Eighty women undergoing a total abdominal hysterectomy under general anesthesia were randomized to receive a placebo (n = 20, group 1), ondansetron 2 mg before induction and 2 mg after surgery (n = 20, group 2), ondansetron 4 mg before induction (n = 20, group 3), or ondansetron 4 mg after surgery (n = 20, group 4). An IV-PCA using butorphanol and ketorolac was connected to the patients after waking from the anesthesia. The incidences and severity of nausea and vomiting were recorded for 48 hr postop. RESULTS: The incidences of nausea and vomiting in group 1 (75%, 40%) were significantly decreased after ondansetron administration but there were no significant differences among the ondansetron groups (group 2; 45%, 20%, group 3; 45%, 15%, group 4; 40%, 10%) (P < 0.05). CONCLUSIONS: The prophylactic administration of ondansetron is effective in preventing PONV during IV-PCA, but the timing of ondansetron administration has no effect on its efficacy.
