Effect of Epidural Ketamine Combined with Bupivacaine and Meperidine on Postoperative Pain and Analgesic Consumption after Cesarean Section.
10.4097/kjae.2001.41.1.39
- Author:
Hae Jin LEE
1
;
Choon Ho SUNG
Author Information
1. Department of Anesthesiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Analgesia: epidural;
patient-controlled;
Analgesics: bupivacaine;
ketamine;
meperidine;
Pain: postoperative
- MeSH:
Analgesia;
Analgesia, Epidural;
Analgesics;
Anesthesia, Epidural;
Bupivacaine*;
Catheterization;
Catheters;
Cesarean Section*;
Female;
Humans;
Ketamine*;
Meperidine*;
N-Methylaspartate;
Pain, Postoperative*;
Pregnancy;
Recovery Room
- From:Korean Journal of Anesthesiology
2001;41(1):39-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with analgesic properties. This study was undertaken to evaluate the potential utility of epidural ketamine combined with meperidine and bupivacaine for postoperative patient-controlled epidural analgesia (PCEA) after cesarean section. METHODS: Forty-five patients received epidural catheterization in the L3-4 intervetebral space and underwent cesarean section under epidural anesthesia. In the recovery room, these patients were randomly allocated to 3 groups; group I (control; n = 15) received 1 mg/ml bupivacaine and 1 mg/ml meperidine, group II (n = 15) received 1 mg/ml bupivacaine and 1 mg/ml meperidine with 0.25 mg/ml ketamine, group III (n = 14) received 1 mg/ml bupivacaine and 1 mg/ml meperidine with 0.75 mg/ml ketamine using a PCEA device for postoperative pain control. The analgesic effects and PCEA consumption were assessed at 6, and 24 hours after surgery. Side effects were also evaluated. RESULTS: There were no statistically significant differences in the visual analogue scale for pain, the consumption of the analgesics and side effects among the groups. CONCLUSIONS: Epidural ketamine combined with bupivacaine and meperidine did not improve postoperative analgesia, nor did it reduce consumption of the analgesics and side effects.
