Dose-response relationship between cigarette smoking and female sexual dysfunction.
10.5468/ogs.2015.58.4.302
- Author:
Joohee CHOI
1
;
Dong Wook SHIN
;
Seungmee LEE
;
Myung Jae JEON
;
Sun Min KIM
;
Belong CHO
;
Seung Mi LEE
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. smleemd@hanmail.net
- Publication Type:Original Article
- Keywords:
Dose-response relationship;
Female;
Nicotine;
Sexual dysfunctions;
Smoking
- MeSH:
Confounding Factors (Epidemiology);
Female;
Humans;
Nicotine;
Risk Factors;
Smoke;
Smoking*
- From:Obstetrics & Gynecology Science
2015;58(4):302-308
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: To evaluate whether smoking is a risk factor for female sexual dysfunction (FSD) and to determine the relationship between the cumulative smoking dose and FSD in premenopausal women. METHODS: The study population consisted of sexually active premenopausal women. The frequency of FSD and female sexual function index (FSFI) total score were evaluated according to the smoking status (never/former and current smokers). Evaluation of sexual function was done using FSFI questionnaire, and women with FSFI score of < or =26.55 were considered to have FSD. In current smokers, sexual function was also evaluated according to the cumulative smoking dose and nicotine dependency. RESULTS: A total of 900 women were included, and the frequency of current smokers and the frequency of FSD were 62 (6.9%) and 496 (55.1%), respectively. In current smokers, the frequency of FSD was significantly higher and the median total FSFI score was significantly lower than in never/former smokers, and this difference of FSD remained significant after adjustment for confounding variables. Among current smokers, the cumulative smoking dose (pack-years) and the total FSFI score showed negative correlation, in which increased cumulative smoking dose was associated with lower total FSFI score (r=-0.278, P<0.05). In terms of nicotine dependency, the total FSFI score of moderately to heavily nicotine dependent smokers was significantly lower than that of lightly dependent smokers. CONCLUSION: In premenopausal women, current smoking was an independent risk factor for FSD. And cumulative smoking dose and nicotine dependency were associated with higher risk of FSD.
