Prognostic Impact of Polymorphisms in the CASPASE Genes on Survival of Patients with Colorectal Cancer.
- Author:
Jun Young CHOI
1
;
Jong Gwang KIM
;
You Jin LEE
;
Yee Soo CHAE
;
Sang Kyun SOHN
;
Joon Ho MOON
;
Byung Woog KANG
;
Min Kyu JUNG
;
Seong Woo JEON
;
Jun Seok PARK
;
Gyu Seog CHOI
Author Information
1. Department of Oncology/Hematology, Kyungpook National University Medical Center, Kyungpook National University School of Medicine, Daegu, Korea. jkk21c@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal neoplasms;
Caspases;
Genetic polymorphism;
Prognosis
- MeSH:
Adenocarcinoma;
Carcinoembryonic Antigen;
Caspase 3;
Caspases;
Colonic Neoplasms;
Colorectal Neoplasms;
DNA;
Humans;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Prognosis;
Rectal Neoplasms;
Reverse Transcription
- From:Cancer Research and Treatment
2012;44(1):32-36
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: This study analyzed potentially functional polymorphisms in CASPASE (CASP) genes and their impact on the prognosis for Korean colorectal cancer patients. MATERIALS AND METHODS: A total of 397 consecutive patients with curatively resected colorectal adenocarcinoma were enrolled in this study. Genomic DNA from these patients was extracted from fresh colorectal tissue, and the 10 polymorphisms in the CASP3, CASP6, CASP7, CASP8, CASP9, and CASP10 genes were determined using a reverse transcription polymerase chain reaction genotyping assay. RESULTS: The median patient age was 63 years, and 218 (54.9%) patients had colon cancer, while 179 (45.1%) patients had rectal cancer. Univariate and multivariate survival analysis including pathologic stage, patient age, differentiation, and carcinoembryonic antigen level demonstrated that these polymorphisms were not associated with either disease-free or overall survival. CONCLUSION: None of the 10 polymorphisms in the CASP genes investigated in this study was found to be an independent prognostic marker for Korean patients with curatively resected colorectal cancer.
