Comparative Study of Ondansetron versus Droperidol versus Placebo to Prevent Postoperative Nausea and Vomiting after Strabismus in Children.
10.4097/kjae.1994.27.11.1639
- Author:
Chang Hyun LEE
1
;
Jun Hak LEE
;
Ki Nam LEE
;
Jun Il MOON
Author Information
1. Department of Anesthesiology, Presbyterian Medical Center, Chonju, Korea.
- Publication Type:Comparative Study ; Original Article
- Keywords:
Ondansetron;
Droperidol;
Postoperative;
Nausea;
Vomiting
- MeSH:
Anesthesia;
Child*;
Droperidol*;
Humans;
Nausea;
Ondansetron*;
Postoperative Nausea and Vomiting*;
Postoperative Period;
Strabismus*;
Vomiting
- From:Korean Journal of Anesthesiology
1994;27(11):1639-1645
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Postoperative nausea and vomiting is a troublesome problem in pediatric patients undergo- ing strabismus surgery. We compared the effects of ondansetron with those of droperidol and placebo within the 24hrs postoperative period. 54 children, who admitted to Presbyteri- an Medical Center to receive strabismus operations, with ASA physical status 1, were as- signed to one of three groups according to uncontrolled parallel comparative study design. A standard anesthetic technique consisting of thiopental-vecuronium for induction and N2O-O2-enflurane for maintenance of anesthesia was used. The data showed that ondansetron 0. 067mg/kg i.v. before induction was significantly more effective in preventing emesis (n=19, 100%) than placebo(n=17, 58.8%). But, there was no significant difference between droperidol group and placebo group. In conclusion, ondansetron(0.067mg/kg) given intravenously before induction to prevent postoperative nausea and vomiting in patients undergoing elective strabismus surgery in children was effective.
