Efficacy of 14 Day OBMT Therapy as a Second-line Treatment for Helicobacter pylori Infection.
- Author:
Sung Chul PARK
1
;
Hoon Jai CHUN
;
Sung Woo JUNG
;
Bora KEUM
;
Woo Sik HAN
;
Rok Son CHOUNG
;
Yong Sik KIM
;
Yoon Tae JEEN
;
Hong Sik LEE
;
Soon Ho UM
;
Sang Woo LEE
;
Jai Hyun CHOI
;
Chang Duck KIM
;
Ho Sang RYU
;
Jin Hai HYUN
Author Information
1. Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea. kumcge@chollian.net
- Publication Type:Original Article ; English Abstract
- Keywords:
Helicobacter pylori;
Retreatment;
Eradication
- MeSH:
Adult;
Antacids/administration & dosage;
Anti-Bacterial Agents/administration & dosage;
Anti-Ulcer Agents/administration & dosage;
Bismuth/administration & dosage;
Drug Therapy, Combination;
English Abstract;
Female;
Helicobacter Infections/*drug therapy;
*Helicobacter pylori;
Humans;
Male;
Metronidazole/administration & dosage;
Middle Aged;
Omeprazole/administration & dosage;
Retreatment;
Tetracycline/administration & dosage
- From:The Korean Journal of Gastroenterology
2004;44(3):136-141
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: As a second-line treatment for H. pylori eradication in the case of first-line OAC (omeprazole, amoxicillin, clarithromycin) treatment failure, a minimum of one-week OBMT quadruple therapy composed of omeprazole, bismuth, metronidazole, tetracycline has been recommended in European countries and one or two weeks in USA. In Korea, one-week OBMT quadruple therapy is recommended for the case of first-line OAC treatment failure. Because H. pylori eradication rate of one-week OBMT therapy in Korea is about 80%, the eradication rate of one week therapy is not satisfactory. We analyzed the effect of two-week second-line OBMT therapy. METHODS: Between June 2002 and June 2003, 107 patients who were H. pylori positive (44 males and 63 females: mean age 51.8 years) after primary eradication therapy received two-week OBMT therapy. Four weeks after completion of therapy, 13C-urea breath test was performed to detect H. pylori. RESULTS: After two weeks of OBMT therapy, eradication was achieved in 103 of 107 patients (96.3%) and in 68 of 71 peptic ulcer patients (95.8%). CONCLUSIONS: Two-week OBMT therapy should be considered as a retreatment regimen with the eradication rate more than 90%.
