The Therapeutic Effect of Levocabastine Eye Drops on Allergic Conjunctivitis: A Multicenter Study.
- Author:
Hyo Myung KIM
;
Shin Jeong KANG
;
Ki San KIM
;
Man Soo KIM
;
Jae Deok KIM
;
Jae Chan KIM
;
Yoon Won MYUNG
;
Yeoung Gcol PARK
;
Woo Chan PARK
;
Jong Chul SHIN
;
Kyung In WOO
;
Jong Soo LEE
;
Jong Hyuck LEE
;
Chang Yeun LEEN
;
Ila Bum LEE
;
Won Ryang WEE
;
Sung Kun CHUNG
;
Jang Ilyun CHUNG
;
Kyung Hyun JIN
;
Si Hwan CHOI
;
Sung Bum HONG
;
Sung Pyo HONG
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Allergic conjunctivitis;
Levocabastine;
Skin test;
Topical
- MeSH:
Administration, Topical;
Conjunctivitis, Allergic*;
Edema;
Foreign Bodies;
Humans;
Ophthalmic Solutions*;
Research Personnel;
Sensation;
Skin Tests
- From:Journal of the Korean Ophthalmological Society
1997;38(12):2120-2128
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The efficacy nd tolerance of topical administration of levocabastine(0.5mg/ml)were evaluated in patients with allergic conjunctivitis. A total of 166 patients who had a typical history of atopy and a positive skin test were recruited in this study. Five clinicl symptoms(itch, tearing, chemosis, lid edema and conjunctival injection) were assessed according to a four point scale before the treatment and at 1 and 2 weeks post-therapy. Total symptom severity score before the therapy, 6.68, was remarkably decreased to 2.86 at 1 week and 2.08 at 2 weeks after the treatment. The investigators rated the treatment as globally good or excellent in 68.1% of patients checked at 1 week and 72.5% at 2 weejs after treatment. And the patients evaluated that the therapy ws good to excellent in 66.9% at 1 week and 73.1% at 2 weeks after treatment. Levocabastine eye drops has a fast onet of action with 55.4% of the patients feeling symptom relief within 15 minutes after the first administration. The adverse effect was experienced in 44 patients. Ocular irritation sign, such as foreign body sensation or soreness, was the most frequently reported complaint. These results suggest that levocabastine eye drops is an effective and safe topical alternative for treatment of allergic conjunctivitis.
